Spike proteins last in the body, lingering for a year or more.  Regardless of the mechanism of how the body acquired spike proteins whether through a direct SARS-CoV infection (meaning you had a Covid-19 infection) or through an mRNA or similar Covid-19 vaccination, spike proteins may in the body, lingering for an unknown amount of time. For all we presently know, spike proteins and their presence in the body are insidious. They apparently have caused strange reactions from myocarditis to all sorts of damage to the body’s systems and organs. Most of these affects remain unknown. As the government says, mitigation of the Covid-19 benefits the vast majority of people, and only affects the few. Â
WHAT IF YOU ARE PART OF THE FEW?
Thankfully, research is ongoing and so far, as of the below article of November 23, 2023 we are learning how to get rid of, or lessen the effects of these devastating spike proteins: "Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination" Nicolas Hulscher • Brian C. Procter • Cade Wynn • Peter A. McCullough Published: November 21, 2023 DOI: 10.7759/cureus.49204
(Peer-Reviewed)Â
SARS-CoV-2 spike protein is a highly persistent, potentially pathogenic substance that may incite inflammation and tissue damage in almost all organ systems, resulting in post-acute sequelae. The vaccine-generated spike protein is different from the viral type, but both have been associated with deleterious effects and persistence in biological systems. Thus, therapeutics that target spike protein may be essential in treating COVID-19, its long-term effects, and possibly COVID-19 vaccine injury syndromes. Base spike detoxification is a promising proposal designed to theoretically attenuate spike protein and its associated damage. However, more pre-clinical and clinical research is needed culminating with large-scale, prospective, randomized, double-blind, placebo-controlled randomized trials to fully assess safety and efficacy. Moreover, further investigation is essential to ensure vaccine-produced, stabilized prefusion spike protein safety and half-life in humans and that it does not possess the same deleterious effects as the viral spike protein.
Abstract of the research article:Â "Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination"Â
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. COVID-19 vaccines utilize a modified, stabilized prefusion spike protein that may share similar toxic effects with its viral counterpart. The aim of this study is to investigate possible mechanisms of harm to biological systems from SARS-CoV-2 spike protein and vaccine-encoded spike protein and to propose possible mitigation strategies. We searched PubMed, Google Scholar, and ‘grey literature’ to find studies that (1) investigated the effects of the spike protein on biological systems, (2) helped differentiate between viral and vaccine-generated spike proteins, and (3) identified possible spike protein detoxification protocols and compounds that had signals of benefit and acceptable safety profiles.Â
We found abundant evidence that SARS-CoV-2 spike protein may cause damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. Viral and vaccine-encoded spike proteins have been shown to play a direct role in cardiovascular and thrombotic injuries from both SARS-CoV-2 and vaccination. Detection of spike protein for at least 6-15 months after vaccination and infection in those with post-acute sequelae indicates spike protein as a possible primary contributing factor to long COVID.
This is what we know and how to detoxify Base Spike Protein:
We found abundant evidence that SARS-CoV-2 spike protein may cause biological damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. Mechanistically, spike protein has been shown to cause dysfunction in many cell types by causing metabolic deteriorations, leading to cell death. Stabilized prefusion (vaccine-derived) spike protein may possess similar harmful mechanisms as viral spike protein. Spike protein is found, in the absence of nucleocapsid, directly in cardiomyocytes and blood clots in patients diagnosed with myocarditis and acute stroke, respectively. Vaccine-derived and viral spike proteins have been found in humans for at least 6-15 months after vaccination or infection in those with post-acute sequelae, indicating spike protein as a possible primary contributing factor to long COVID, with substantial persistence in human systems due to the absence of an innate clearing mechanism. However, more research is needed to further investigate the effect of spike protein in patients with post-acute sequelae after COVID-19 and COVID-19 vaccination. Meanwhile, the current data points to a strong signal to urgently develop spike protein detoxification protocols.
Although methods to degrade or block spike protein have been investigated, there are currently no widely accepted protocols to do this in human subjects. The McCullough protocol: base spike detoxification is the first protocol established to help remove spike protein derived from SARS-CoV-2 infection and vaccination in humans. The three-drug regimen of nattokinase, bromelain, and curcumin was chosen due to their proven safety records, as well as their anti-inflammatory and anti-coagulant properties combined with their synergistic and potent effects in degrading and inhibiting spike protein. This protocol may be useful in the attenuation of COVID-19 vaccine-induced injury syndromes and long-term COVID-19 complications.
The addition of other agents that can further assist in the detoxification of spike protein may be indicated based on clinical outcomes. Most notably, the addition of N-acetylcysteine (NAC) may add an extra mechanism of action against spike protein to the protocol. NAC has been shown to disrupt disulfide bonds of the spike protein, rendering it unable to bind to the ACE2 receptor. Moreover, the combination of NAC with bromelain has been shown to synergistically disrupt spike protein by breaking glycosidic linkages and disulfide bonds. NAC has a well-established safety profile and is commonly taken at a dose of 600 mg twice a day. Thus, the addition of NAC to the regimen of bromelain, curcumin, and nattokinase may be useful for individuals with severe treatment-resistant COVID-19 or COVID-19 vaccine-related complications. Since all of these compounds can reduce blood clotting, patients should be counseled and monitored for bleeding complications, including easy bruising, nasal mucosal bleeding, and gastrointestinal hemorrhage. Self-administration is not advised without physician oversight.
Dissolution of spike protein-induced thrombus. Nattokinase directly degrades fibrinolysis-resistant fibrin (from spike protein), and bromelain upregulates fibrinolysis. B: Inhibition of spike protein via ACE2 receptors. Bromelain and curcumin block the ACE2 receptor, preventing spike protein from binding. C: Proteolytic degradation of spike protein.
Nattokinase and bromelain degrade spike proteins, rendering them inactive. D: Attenuation of spike protein-induced inflammation. Bromelain and curcumin downregulate the NF-kB signaling pathway induced by spike protein, leading to the suppression of inflammatory molecules. E: BSD treatment protocol. The full treatment regimen and the addition of other compounds based on clinical indication are illustrated.
Bromelain, a proteolytic enzyme sourced from the stem of pineapples, has been traditionally hailed for its healing and anti-inflammatory capabilities, particularly in cases of arthritis and injury. Of significance is bromelain's anticoagulant activity. It downregulates PGE-2 and thromboxane A2, promoting a relative prostacyclin abundance in platelets. Furthermore, it aids in fibrinolysis by promoting plasminogen conversion to plasmin and inhibiting platelet aggregation. Kritis et al. demonstrated that bromelain can obstruct SARS-CoV-2's entry into cells by cleaving its spike protein and reducing ACE2 and TMPRSS2 expression. This enzyme can also hydrolyze glycosidic linkages, which comprise spike protein’s glycosidic shield that helps protect it from immune responses. To attenuate inflammation, bromelain, in part, downregulates the pro-inflammatory prostaglandin E−2 (PGE-2) through inhibition of NF-kB and cyclooxygenase 2 and inhibits inflammatory mediators . Thus, bromelain exerts multiple mechanisms of action against spike protein’s toxic effects and persistence. Bromelain has been used as a daily dosage of 200-2,000 mg; thus, 500 mg is a suggested initial dose. Bromelain is mainly safe with low toxicity, but it can amplify bleeding risk and affect the absorption rate of several medications, potentially leading to drug interactions.
Curcumin, a polyphenol extracted from turmeric, is renowned for its anti-inflammatory properties and its ability to modulate inflammation during viral infections. Curcumin also supports fibrinolysis and the process of anticoagulation. Beyond its traditionally recognized benefits, curcumin has shown promising antiviral actions against a wide range of viruses, including influenza, hepatitis, and notably, SARS-CoV-2. It achieves this by obstructing the spike protein's binding sites (ACE2 receptors and TMPRSS-2).
Hydroxychloroquine, a well-known FDA-approved antimalarial and anti-inflammatory, adds additional support for immunocompromised patients by inhibiting the binding of spike protein to human cells.
Colchicine, an FDA-approved alkaloid found in the plants Colchicum autumnale and Gloriosa superba, has been traditionally used in therapeutics for its anti-inflammatory properties. This compound can reduce the risk of myocardial infarction and stroke. Moreover, colchicine may reduce myocardial injury in the presence of spike protein.
Additional compounds that may assist in spike protein detoxification and degradation include the following:
N-Acetylcysteine (NAC):Â It dissolves spike protein through the destruction of disulfide bonds and prevents binding at ACE2
Glutathione: It disrupts spike protein disulfide bonds
Ivermectin: It binds and inhibits spike protein
Quercetin:Â It binds and inhibits spike protein
Apigenin:Â It binds and inhibits spike protein (abundant in fruits & many vegetables)
Nicotine: It disrupts glycosylation on spike protein and blocks possible spike protein-nicotinic cholinergic receptor interaction  ( I don’t advocate smoking)
Emodin: It blocks the spike protein-ACE2 interaction  (this is present in rhubarb & buckthorn)
Fisetin: It binds and inhibits spike protein  (present in fruits, berries, kiwis, grapes)
Rutin:Â It binds and inhibits spike protein (an anti-oxidant in apples, buckwheat, figs)
Silymarin:Â It binds and inhibits spike protein (anti-inflammatory, present in milk thistle)
We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-term post-infection and/or vaccine-induced complications.
We propose a base spike detoxification protocol, composed of oral nattokinase, bromelain, and curcumin. This approach holds immense promise as a base of clinical care, upon which additional therapeutic agents are applied with the goal of aiding in the resolution of post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination.