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Predicting Long COVID at initial point of COVID-19 diagnosis:

Study finds several warning factors

ate: January 25, 2022

Source: Institute for Systems Biology


A study has identified four predictive factors of Post Acute Sequelae of COVID-19 (PASC), often called long COVID. These 'PASC factors' can be identified at the initial point of COVID-19 diagnosis and can anticipate if a patient is likely to develop long COVID. Additionally, researchers found that mild cases of COVID-19, not just severe cases, are associated with long COVID, and that administering antivirals very early in the disease course may potentially prevent some PASC. Share:

FULL STORY: A significant portion of people who contract the SARS-CoV-2 virus -- some estimates suggest more than 40 percent -- suffer chronic effects known as Post Acute Sequelae of COVID-19 (PASC), commonly referred to as long COVID. PASC symptoms include fatigue, brain fog, the loss of taste and smell, shortness of breath, and more.

Now, researchers have identified several factors that can be measured at the initial point of COVID-19 diagnosis that anticipate if a patient is likely to develop long COVID. These "PASC factors" are the presence of certain autoantibodies, pre-existing Type 2 diabetes, SARS-CoV-2 RNA levels in the blood, and Epstein-Barr virus DNA levels in blood. "Identifying these PASC factors is a major step forward for not only understanding long COVID and potentially treating it, but also which patients are at highest risk for the development of chronic conditions," said ISB President, Dr. Jim Heath, co-corresponding author of a research paper that will be published by the journal Cell. "These findings are also helping us frame our thinking around other chronic conditions, such as post-acute Lyme syndrome, for example."

Additionally, researchers found that mild cases of COVID-19, not just severe cases, are associated with long COVID. They also suggest that administering antivirals very early in the disease course may potentially prevent some PASC. "Long COVID is causing significant morbidity in survivors of COVID-19, yet the pathobiology is poorly understood," said Dr. Jason Goldman, co-corresponding author of the paper and an infectious disease expert at Swedish. "Our study pairs clinical data and patient-reported outcomes with deep multi-omic analyses to unravel important biological associations that occur in patients with PASC. Certain findings such as the low cortisol state in patients with long COVID have potential to translate rapidly to the clinic. Our results form an important foundation for the development of therapeutics to treat long COVID."

Researchers collected blood and swab samples from 309 COVID-19 patients at different time points to perform comprehensive phenotyping which was integrated with clinical data and patient-reported symptoms to carry out a deep multi-omic, longitudinal investigation.

A key finding from the study deals with viral load, which can be measured near diagnosis to predict long COVID symptoms. "We found that early blood viral measurements are strongly associated with certain long COVID symptoms that patients will develop months later," said Dr. Yapeng Su, a co-first and co-corresponding author of the paper. In addition, researchers found the Epstein-Barr virus (EBV) -- a virus that infects 90 percent of the human population and is normally inactive in the body after infection -- is reactivated early on after SARS-CoV-2 infection, which is significantly associated with future long COVID symptoms. "This may be related to immune dysregulation during COVID-19 infection," Su added.

The team also found that PASC is anticipated by autoantibodies (which associate with autoimmune diseases like lupus) at diagnosis, and that as autoantibodies increase, protective SARS-CoV-2 antibodies decrease. This suggests a relationship between long COVID, autoantibodies and patients at elevated risk of re-infections. "Many patients with high autoantibodies simultaneously have low (protective) antibodies that neutralize SARS-CoV-2, and that's going to make them more susceptible to breakthrough infections," said Daniel Chen, a co-first author of the paper. The research project was a collaboration between ISB, Providence, Swedish the University of Washington, Fred Hutchinson Cancer Research Center, Stanford, UCLA, UCSF, and others. Story Source: Materials provided by Institute for Systems Biology. Note: Content may be edited for style and length.

Journal Reference: Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A. Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L. Dai, Priyanka Baloni, Brett Smith, Venkata R. Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A. Algren, William R. Berrington, Julie A. Wallick, Rebecca A. Cochran, Mary E. Micikas, Christos J. Petropoulos, Hunter R. Cole, Trevan D. Fischer, Wei Wei, Dave S.B. Hoon, Nathan D. Price, Naeha Subramanian, Joshua A. Hill, Jennifer Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D. Goldman, James R. Heath. Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 2022; DOI: 10.1016/j.cell.2022.01.014

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